Pregnant transfusions can increase the risk of mortality

Women’s transfusion in men, especially those below 50, was pregnant, they may be associated with an increased risk of death of all causes compared to that transfusion in women or pregnant transfusions than ever-sex users of the online study published on October 17 at Jamaica .

Since 2011, several studies have shown that transfusion women are more risky for transfusion recipients than men, and that this risk is higher in pregnant women. The most common cause of mortality due to transfusion, acute lung injury is associated with the use of plasma gamma products, indicating an immunologically mediated antibody response.

In order to investigate these connections, we analyzed more Camila Caram-Deelder, PhD studies at Sanquin Research, Leiden, Netherlands, and transfusion staff of red blood cell transfusions of female donor blood, pregnant or not, and mortality in male and female recipients. Sanquin is the source of blood in the Netherlands, and every blood is bad in leukocytes.

The researchers used a retrospective group of individuals who received the first transfusion since May 30, 2005 and September 1, 2015 in one of the 6 major Dutch hospitals. They analyzed the age and gender of the recipient as well as the history of sex and pregnancy (if known) donors. Some data was recorded before asking about the condition of pregnancy.

The original database containing 42,132 patients was treated with 106,641 red blood cells (76% male volunteers, 12% pregnant donors, 12% non-pregnant donors). These groups, the researchers have further studied the cohort study of 31,188 patients receiving 59,320 red blood cell units exclusively from male volunteers exclusively from donors without pregnancy pregnancy (never pregnant donors), exclusively women’s donors with a history of pregnancy (pregnant donors).

The study was followed by 245-day median recipients. The average age of the recipient was 65 and 16.123 (52%) were women. 3969 people died

The risk ratio (HR) for death following receipt of the red blood cell extraction unit from non-pregnant female donor was compared with the male donor unit 0.93 (95% confidence interval [CI, 0.81 to 1.06] for male recipients and 1 , 01 (95% CI, 0.88-1.15) for women users. In contrast, HR is the death of an additional red blood cell donor unit that is always pregnant when compared to male donor unit 1.13 (95% CI, 01/01 to 01/26) for male recipients and 0.99 (95% CI, 0.87-1.13) for women users.

The highest increase in mortality was observed in male patients under 50 years of age, donors received transfusion (age 0-18 years HR 1.63, 95% CI, 1.02 to 2.61, age 18 to 50 years: HR, 1.50, 95 % CI, 0.98-2.30).